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Updated: Aug 6, 2026

Pre-clinical Evaluation of Tyrosine Kinase Inhibitors for Treatment of Acute Leukemia
Published on: September 18, 2013
[The therapeutic effects of FLAG regime for refractory and relapsing acute leukemia]
Xiao-jun Huang1, Jin Lu, Dao-pei Lu
1Institute of Hematology and People' Hospital, Peking University, Beijing 100044, China. xjhrm@medmail.com.cn
Objective:
To investigate the therapeutic effects of FLAG regimen for refractory and relapsing acute leukemia.
Methods:
Fludarabine 30 mg.m(-2).d(-1), 3 - 5 days, Ara-C 1.5 g.m(-2).d(-1), 5 d and, G-CSF 5 microg.kg(-1).d(-1) were used to treat 7 cases (10 times) of refractory and relapsed leukemia.
Results:
Of the 10 times, nine showed response to therapy; one case died of complication. Neutropenia begin at the time of 5 - 12 days after the regimen initiating and last 5 - 34 days, thrombocytopenia begin at 5 - 18 days and last 5 - 36 days. The adverse reaction includes hyperamino transferase, pyrexia and diarrhea.
Conclusion:
FLAG shows obvious effects for refractory and relapsing acute leukemia and gains time for hematopoietic stem cell transplantation.
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