Related Experiment Video

Updated: Sep 20, 2026

Electrophoretic Analysis of Replication Through Structure-Prone DNA Repeats Within the SV40-Based Human Episome
05:22

Electrophoretic Analysis of Replication Through Structure-Prone DNA Repeats Within the SV40-Based Human Episome

Published on: September 13, 2024

Simian virus 40 and its association with human lymphomas

Regis A Vilchez1, Janet S Butel

  • 1Department of Medicine, Baylor College of Medicine, Mail Stop BCM-385, One Baylor Plaza, Houston, TX 77030, USA.

Current Oncology Reports
|August 5, 2003
PubMed

Insights

Simian virus 40 (SV40) is a DNA tumor virus linked to various cancers in animals and humans. Research suggests SV40 may play a role in human lymphoma development.

Area of Science:

  • Oncology
  • Virology
  • Molecular Biology

Background:

  • Simian virus 40 (SV40) is a DNA tumor virus known to cause cancer in animals.
  • SV40 oncogenesis involves the viral large tumor antigen inactivating tumor suppressor proteins.
  • SV40 is recognized as an emergent human pathogen.

Purpose of the Study:

  • To review evidence implicating SV40 in human lymphoma pathogenesis.
  • To discuss future research directions for defining SV40's causative role in malignancies.

Main Methods:

  • Review of experimental and clinical data.
  • Analysis of studies linking SV40 to human cancers.
  • Examination of SV40 markers in human malignancies.

Main Results:

  • SV40 induces brain cancers, mesothelioma, bone cancers, and lymphomas in animals.
  • SV40 is associated with an increased risk of human brain cancers, mesothelioma, bone cancers, and non-Hodgkin's lymphoma.
  • Tumors induced by SV40 in animals share similarities with human malignancies containing SV40 markers.

Conclusions:

  • SV40 may be functionally important in the development of certain human malignancies.
  • The Institute of Medicine concluded SV40 infections could potentially cause cancer in humans.
  • Further research is needed to definitively establish SV40's causative role in human lymphomas.

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