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Cyclooxygenase enzymes in allergic inflammation and asthma
Michelle A Carey1, Dori R Germolec, Robert Langenbach
1Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, 111 Alexander Drive Mail Drop D2-02, Research Triangle Park, NC 27709, USA.
Abstract:
The cyclooxygenase enzyme system produces eicosanoids which mediate many important physiological and pathological functions. Experimental and clinical data suggest a role for this enzyme system in the pathogenesis of allergic inflammation and asthma. This article focuses on the function of this pathway in the lung, reviews evidence implicating the involvement of this pathway in asthma and allergic airway inflammation, and discusses implications for the treatment of asthmatics with cyclooxygenase inhibitors.