Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hematopoietic prostaglandin D synthase.

Yoshihide Kanaoka1, Yoshihiro Urade

  • 1Department of Medicine, Harvard Medical School, Brigham and Women's Hospital, Smith Building, Room 626C One Jimmy Fund Way, Boston, MA 02115, USA. ykanaoka@rics.bwh.harvard.edu

Prostaglandins, Leukotrienes, and Essential Fatty Acids
|August 5, 2003
PubMed
Summary

Prostaglandin D2 (PGD2) plays key roles in inflammation and immunity. This review details the molecular biology of hematopoietic PGD synthase (H-PGDS), the enzyme responsible for PGD2 production.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Urinary prostaglandin D<sub>2</sub> and E<sub>2</sub> metabolites are elevated with disease severity in patients with Fukuyama congenital muscular dystrophy.

Scientific reports·2025
Same author

Lipocalin-type prostaglandin D synthase: a glymphopathy marker in idiopathic hydrocephalus.

Frontiers in aging neuroscience·2024
Same author

Low-dose radiation induces unstable gene expression in developing human iPSC-derived retinal ganglion organoids.

Scientific reports·2023
Same author

Attenuation of Laser-Induced Choroidal Neovascularization by Blockade of Prostaglandin D2 Receptor 2.

Translational vision science & technology·2023
Same author

Oligodendrocyte-lineage cell exocytosis and L-type prostaglandin D synthase promote oligodendrocyte development and myelination.

eLife·2023
Same author

Hematopoietic Prostaglandin D2 Synthase Controls Tfh/Th2 Communication and Limits Tfh Antitumor Effects.

Cancer immunology research·2022

Area of Science:

  • Immunology
  • Biochemistry
  • Pharmacology

Background:

  • Prostaglandin D2 (PGD2) mediates critical biological actions, including vasodilation, bronchoconstriction, and inflammatory cell recruitment.
  • The identification of CRTH2 as a novel PGD2 receptor and studies of DP receptor null mice highlight PGD2's role in immune and inflammatory responses.

Purpose of the Study:

  • This review focuses on the molecular biology of hematopoietic PGD synthase (H-PGDS).
  • It aims to elucidate the structure, gene expression regulation, and functional insights from transgenic models of H-PGDS.

Main Methods:

  • Review of existing literature on H-PGDS.
  • Analysis of structural data for H-PGDS.
  • Examination of gene expression studies and transgenic animal models.

Related Experiment Videos

Main Results:

  • H-PGDS is a cytosolic enzyme catalyzing PGD2 synthesis from PGH2 in a glutathione-dependent manner.
  • H-PGDS is the sole mammalian Sigma class cytosolic glutathione S-transferase, expressed in immune cells like mast cells, antigen-presenting cells, and Th2 cells.

Conclusions:

  • Understanding H-PGDS is crucial for comprehending PGD2-mediated inflammatory and immune processes.
  • Further research into H-PGDS offers potential therapeutic targets for inflammatory diseases.