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[Clinical evaluation of cefprozil granules in pediatric field]

S Furukawa1, T Okada

  • 1Department of Pediatrics, Kagawa Children Hospital, National Sanatrium.

The Japanese Journal of Antibiotics
|December 1, 1992
PubMed

Insights

Cefprozil (CFPZ) granules demonstrated 100% clinical efficacy in treating pediatric bacterial infections like tonsillitis and bronchitis. This study found no adverse side effects in children, suggesting CFPZ is a safe and effective treatment option.

Area of Science:

  • Pediatric Infectious Diseases
  • Bacteriology
  • Pharmacology

Background:

  • Bacterial infections are a common cause of illness in children.
  • Effective and safe antibiotic options are crucial for pediatric care.
  • Cefprozil is a cephalosporin antibiotic with broad-spectrum activity.

Purpose of the Study:

  • To evaluate the clinical efficacy and safety of Cefprozil (CFPZ) granules in pediatric patients.
  • To assess the effectiveness of CFPZ in treating various bacterial infections in children.
  • To determine the incidence of adverse effects associated with CFPZ treatment in this population.

Main Methods:

  • A total of 20 pediatric patients with bacterial infections received Cefprozil (CFPZ) granules.
  • Daily doses ranged from 29-50 mg/kg, administered orally three times daily for 5 to 9 days.
  • Clinical efficacy and adverse events were monitored throughout the treatment period.

Main Results:

  • Cefprozil (CFPZ) achieved an overall clinical efficacy rate of 100%, with 16 cases showing excellent results and 4 cases showing good results.
  • No adverse side effects were reported in any of the pediatric patients during the study.
  • One case of thrombocytosis was noted as an abnormal laboratory finding.

Conclusions:

  • Cefprozil (CFPZ) granules are highly effective in treating pediatric bacterial infections, including acute tonsillitis, acute bronchitis, purulent lymphadenitis, and urinary tract infections.
  • The drug was well-tolerated, with no observed side effects, indicating a favorable safety profile in children.
  • Cefprozil (CFPZ) is considered a useful therapeutic option for bacterial infections in pediatric patients.

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