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[Basic and clinical studies on cefprozil in pediatrics].

Y Kainou1, S Matsumoto, K Kida

  • 1Department of Pediatrics, School of Medicine, Ehime University.

The Japanese Journal of Antibiotics
|December 1, 1992
PubMed
Summary
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Chemical & pharmaceutical bulletin·1992

Cefprozil (CFPZ) demonstrated favorable pharmacokinetics and high urinary excretion after oral administration. Clinical studies showed good responses in pediatric infections with minimal side effects.

Area of Science:

  • Pharmacology
  • Clinical Microbiology
  • Pediatric Infectious Diseases

Background:

  • Cefprozil (CFPZ) is an oral cephalosporin antibiotic.
  • Understanding its pharmacokinetic and clinical efficacy is crucial for effective treatment.

Purpose of the Study:

  • To evaluate the pharmacokinetics of cefprozil (CFPZ) after oral administration.
  • To assess the clinical and bacteriological efficacy of CFPZ in pediatric infections.

Main Methods:

  • Single oral doses of CFPZ (7.5 mg/kg) were administered to assess serum levels and urinary excretion (HPLC).
  • CFPZ was administered daily (19–47.3 mg/kg/day) to 17 pediatric patients with infections.

Main Results:

  • Peak serum levels of CFPZ ranged from 2.9–5.5 µg/ml at 1 hour, with trace levels at 6 hours.

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  • Urinary excretion rates were high, ranging from 45.7–102.3% within 6 hours.
  • All 17 pediatric cases, including 16 respiratory infections and 1 external otitis, showed good clinical and bacteriological responses.

    • Conclusions:

    • Cefprozil exhibits favorable absorption and high urinary excretion.
    • CFPZ is effective and well-tolerated for treating pediatric infections, with diarrhea and eosinophilia as observed side effects.