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[Effects of age, renal diseases and diabetes mellitus on the renal size reduction accompanied by the decrease of
Nihon Jinzo Gakkai Shi
|October 1, 1992
Summary
Kidney size decreases with declining kidney function in healthy individuals and those with chronic renal diseases (CRD) or diabetic nephropathy (DN). Diabetic nephropathy patients showed less size reduction per unit of function loss compared to controls and CRD patients.
Area of Science:
- Nephrology
- Radiology
- Urology
Context:
- Kidney size and function are critical indicators of renal health.
- Ultrasonography is a key imaging modality for assessing renal morphology.
- Chronic renal diseases (CRD) and diabetic nephropathy (DN) significantly impact kidney structure and function.
Purpose:
- To investigate the relationship between renal size and renal function in normal controls, CRD patients, and DN patients.
- To compare the rate of renal size reduction relative to the decline in creatinine clearance (Ccr) across these groups.
Summary:
- A positive correlation between renal size and Ccr was observed in all groups (controls, CRD, DN).
- Renal size reduction per unit decrease in Ccr was similar in controls and CRD patients.
- However, DN patients exhibited a smaller reduction in renal size for a given decrease in Ccr compared to controls and CRD patients.
- At similar levels of severely reduced Ccr (≤20 ml/min), DN kidneys were significantly larger than CRD kidneys, irrespective of illness duration.
Impact:
- This study highlights distinct patterns of renal size changes in diabetic nephropathy compared to other chronic kidney diseases.
- Findings suggest that ultrasonographic assessment of renal size, in conjunction with function tests, can aid in differentiating renal pathologies.
- Understanding these differences is crucial for accurate diagnosis and management of kidney diseases.