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Related Experiment Videos

Prostatic intraepithelial neoplasia (PIN): current concepts.

D G Bostwick1

  • 1Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota 55905.

Journal of Cellular Biochemistry. Supplement
|January 1, 1992
PubMed
Summary

Prostatic intraepithelial neoplasia (PIN) is a precancerous condition. High-grade PIN is a precursor to prostate cancer, indicating the need for further investigation upon detection.

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Area of Science:

  • Urology
  • Oncology
  • Pathology

Background:

  • Prostatic intraepithelial neoplasia (PIN) is a recognized precursor lesion to prostate cancer.
  • It represents a spectrum of cellular changes within prostatic ducts and acini.

Purpose of the Study:

  • To describe the morphologic and molecular characteristics of prostatic intraepithelial neoplasia (PIN).
  • To highlight the clinical significance of identifying PIN in prostate biopsies.

Main Methods:

  • Morphologic analysis of prostatic tissue.
  • Evaluation of cellular differentiation markers.
  • Assessment of nuclear abnormalities and DNA content (aneuploidy).

Main Results:

  • Two grades of PIN (low and high) are identified.
  • High-grade PIN exhibits basal cell and basement membrane disruption, loss of secretory markers, nuclear abnormalities, and aneuploidy.
  • Low-grade PIN emerges in men by their third decade.

Conclusions:

  • High-grade PIN is a direct precursor to invasive prostate cancer.
  • The identification of PIN in prostate biopsies necessitates a thorough search for concurrent carcinoma.

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