Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

DNA ploidy: early malignant lesions.

M M Lieber1

  • 1Mayo Medical School, Mayo Clinic, Rochester, Minnesota 55905.

Journal of Cellular Biochemistry. Supplement
|January 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cytogenetics of prostate cancer.

International journal of urology : official journal of the Japanese Urological Association·2013
Same author

Hepatic Infarction.

The American journal of pathology·2009
Same author

Siderotic Nodules (Gandy-Gamna Bodies) in Primary Renal Carcinoma.

The American journal of pathology·2009
Same author

Intravascular extension of an osteosarcoma of the pubic bone into periprostatic venous plexus.

Urology·2005
Same author

Distribution of the Brief Male Sexual Inventory in community men.

International journal of impotence research·2003
Same author

Incidence of physician-diagnosed interstitial cystitis in Olmsted County: a community-based study.

BJU international·2003

DNA ploidy analysis of prostate cancer reliably predicts patient prognosis. Diploid tumors show better outcomes, especially in advanced stages, suggesting ploidy guides treatment sensitivity.

Area of Science:

  • Oncology
  • Genetics
  • Urology

Background:

  • Prostate cancer diagnosis and staging are critical for treatment planning.
  • Accurate assessment of tumor cell DNA content is essential for prognostic evaluation.

Purpose of the Study:

  • To evaluate the prognostic value of DNA ploidy in prostate cancer.
  • To determine if DNA ploidy can predict response to androgen deprivation therapy.

Main Methods:

  • Standardized flow cytometry and static image cytometry for nuclear DNA content measurement.
  • Analysis of DNA ploidy in various prostate cancer specimen types (biopsies, TUR chips, radical prostatectomies).
  • Correlation of DNA ploidy with clinical stage, grade, and patient prognosis.

Main Results:

Related Experiment Videos

  • DNA diploid prostate tumors demonstrate a better prognosis than non-diploid tumors across all stages (A1-D2).
  • DNA diploid stage D1 and D2 tumors treated with early androgen deprivation have favorable outcomes.
  • Non-diploid tumors progress rapidly despite androgen deprivation, indicating potential hormonal resistance.

Conclusions:

  • DNA ploidy is a significant prognostic marker for prostate cancer.
  • DNA ploidy can identify tumors likely to respond to hormonal manipulation.
  • Early-stage prostate cancers are predominantly diploid, suggesting suitability for chemoprevention strategies.