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Related Experiment Videos

CT imaging of angiogenesis.

T-Y Lee1, T G Purdie, E Stewart

  • 1Imaging Program, Lawson Health Research Institute, London, Ontario, Canada. tell@imaging.robarts.ca

The Quarterly Journal of Nuclear Medicine : Official Publication of the Italian Association of Nuclear Medicine (AIMN) [And] the International Association of Radiopharmacology (IAR)
|August 5, 2003
PubMed
Summary

CT imaging analyzes tumor angiogenesis by modeling contrast agent transport and exchange. This review covers models and practical aspects for quantifying blood flow, volume, and permeability in tumors.

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Area of Science:

  • Radiology and Medical Imaging
  • Oncology
  • Biophysics

Background:

  • Tumor angiogenesis is crucial for solid tumor diagnosis and treatment.
  • Fast, multi-slice CT scanners enable advanced imaging of tumor angiogenesis.
  • CT imaging relies on contrast material transport and diffusion for analysis.

Purpose of the Study:

  • To review CT imaging techniques for qualitative and quantitative analysis of tumor angiogenesis.
  • To discuss compartmental and distributed parameter models for contrast transport and exchange.
  • To highlight practical issues and applications of CT-based angiogenesis quantification.

Main Methods:

  • Utilizing fast CT scanners to measure tissue and vascular enhancement over time.
  • Developing and applying compartmental and distributed parameter models for contrast dynamics.

Related Experiment Videos

  • Measuring the arterial input function for accurate model parameter estimation.

    • Main Results:

    • CT imaging allows detailed modeling of contrast agent distribution in tissues.
    • Models can quantify key angiogenesis parameters: blood flow, volume, transit time, permeability, and hepatic arterial fraction.
    • The Johnson and Wilson distributed parameter model has been applied in experimental studies.

    Conclusions:

    • CT imaging, particularly with advanced models, provides valuable quantitative insights into tumor angiogenesis.
    • Understanding contrast transport and exchange models is essential for accurate angiogenesis assessment.
    • Further application of these CT techniques can aid in tumor diagnosis and treatment strategies.