Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Genetic regulation of osteoclast development and function.

Steven L Teitelbaum1, F Patrick Ross

  • 1Department of Pathology, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8118, St. Louis, Missouri 63110, USA. teitelbs@medicine.wustl.edu

Nature Reviews. Genetics
|August 5, 2003
PubMed
Summary

Osteoclasts are key bone-resorbing cells. Understanding their differentiation and function is crucial for preventing bone loss disorders like osteoporosis, with recent insights from osteopetrosis research.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Siderophore-Antibiotic Heterodimer Imaging Agent Enables <i>In Vivo</i> PET Imaging of <i>S. aureus</i> Infections.

Journal of medicinal chemistry·2026
Same author

Activation of the noncanonical inflammasome-GSDMD pathway triggers pyroptosis in bone marrow and promotes periosteal bone formation.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research·2025
Same author

Activation of the noncanonical inflammasome-GSDMD pathway triggers pyroptosis in bone marrow and promotes periosteal bone formation.

bioRxiv : the preprint server for biology·2025
Same author

Hydroxyapatite microspheres induce durable pleurodesis and are rapidly cleared by pleural osteoclasts.

JCI insight·2025
Same author

The skeletal transcriptional response to mechanical load varies with age and tissue compartment in female mice.

JBMR plus·2025
Same author

PTH pre-treatment prior to tibial mechanical loading improves their synergistic anabolic effects in mice.

Bone·2025

Area of Science:

  • Cell Biology
  • Skeletal Biology
  • Genetics

Background:

  • Osteoclasts are the primary cells responsible for bone resorption.
  • Dysregulation of osteoclast activity contributes to skeletal diseases like osteoporosis.
  • Understanding osteoclast differentiation and function is vital for skeletal health.

Purpose of the Study:

  • To elucidate the mechanisms of osteoclast differentiation and bone resorption.
  • To highlight recent advancements in understanding osteoclast biology.
  • To explore the role of genetic studies, particularly in osteopetrosis, in advancing this knowledge.

Main Methods:

  • Review of recent scientific literature.
  • Analysis of genetic studies focusing on osteoclast function.

Related Experiment Videos

  • Investigation of the hereditary disorder osteopetrosis.

    • Main Results:

    • Significant insights into osteoclast formation and function have emerged in the last five years.
    • Genetic experiments, especially those involving osteopetrosis, have been instrumental in these discoveries.
    • A deeper understanding of osteoclast precursors and their role in bone degradation has been achieved.

    Conclusions:

    • Appreciation of osteoclast mechanisms is essential for preventing pathological bone loss.
    • Osteopetrosis research provides valuable genetic insights into osteoclast biology.
    • Continued research into osteoclast differentiation and function is critical for skeletal health.