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Facile and stereoselective synthesis of 2'-5'-oligothioadenylate by UO2(2+) ion catalyst
M Shimazu1, K Shinozuka, H Sawai
1Department of Chemistry, Faculty of Engineering, Gunma University, Kiryu City, Japan.
Nucleic Acids Symposium Series
|January 1, 1992
Abstract:
The synthesis and characterization of 2'-5'-oligothioadenylate by UO2(2+) ion catalyst are described. The polymerization of imidazole-activated thioadenylate or thioinosylate yielded oligomers containing mainly 2'-5'-internucleotidyl blond and Rp configuration at phosphorous atom.