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Related Experiment Videos

Serotonin effect on deiodinating activity in the rat.

Alessio Sullo1, Guglielmo Brizzi, Nicola Maffulli

  • 1Second University of Naples, Faculty of Medicine and Surgery, Department of Experimental Medicine, Human Physiology Section, Napoli, Italy.

Canadian Journal of Physiology and Pharmacology
|August 5, 2003
PubMed
Summary

Serotonin (5-HT) influences thermoregulation by modulating thyroid hormone production in key organs. This neurotransmitter affects heat production, especially during cold exposure, impacting energy expenditure.

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Area of Science:

  • Endocrinology
  • Neuroscience
  • Metabolism

Background:

  • Serotonin (5-HT) and thyroid hormones interact to regulate eating behavior and energy expenditure.
  • 5-Deiodinase (5-D) activity is crucial for converting thyroxine (T4) to active triiodothyronine (T3) in peripheral tissues.

Purpose of the Study:

  • To investigate the effect of serotonin (5-HT) on 5-Deiodinase (5-D) activity.
  • To assess 5-D activity under basal conditions and during cold exposure (thyroid stimulating hormone stimulation test, TST).

Main Methods:

  • Assessed 5'-D activity in liver, heart, brain, kidney, and intrascapular brown adipose tissue (IBAT).
  • Administered 5-HT before TST to evaluate its modulatory effects.

Main Results:

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  • TST increased 5'-D activity in brain, heart, and IBAT, while decreasing it in the kidney.
  • 5-HT alone did not alter 5'-D activity but decreased it in IBAT, heart, and brain when administered before TST.

Conclusions:

  • Serotonin (5-HT) plays a peripheral role in thermoregulation by modulating intracellular T3 production and heat generation.
  • These effects are pronounced in organs with type II 5'-D (brain, heart, IBAT) during cold-induced upregulation of heat production, influencing energy balance.