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A study on conformationally restricted sangivamycins and their inhibitory abilities of protein kinases
T Iimori1, Y Murai, T Sugiyama
1Faculty of Engineering, Yokohama National University, Japan.
Nucleic Acids Symposium Series
|January 1, 1992
Abstract:
Conformational restrictions of sangivamycin, a rather selective inhibitor of PKC, could be achieved by the use of the steric effect and the gauche effect of the substituents on the ribofuranose moiety. The conformational deviations obtained by these methods were found to nicely correlate with the inhibitory ability of PKC.