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Assessment of Kidney Function in Mouse Models of Glomerular Disease
Published on: June 30, 2018
Glomerular diseases in Iranian children: clinico-pathological correlations
Abbas Madani1, Daryoush Fahimi, Seid Taher Esfehani
1Department of Pediatric Nephrology, Children's Hospital Medical Centre, Tehran University of Medical Sciences, Tehran, Iran.
Pediatric Nephrology (Berlin, Germany)
|August 5, 2003
Summary
This study found minimal-change disease to be the most common glomerular disease in Iranian children. Nephrotic syndrome was the most frequent clinical presentation, highlighting key patterns in pediatric kidney disease.
Area of Science:
- Pediatric Nephrology
- Renal Pathology
- Clinical Medicine
Background:
- Glomerular diseases are a significant component of renal pathology.
- Understanding the spectrum of these diseases in pediatric populations is crucial for effective management.
Purpose of the Study:
- To characterize the types of glomerular diseases diagnosed via native kidney biopsy in Iranian children.
- To correlate these pathological diagnoses with their corresponding clinical presentations.
- To provide insights into pediatric renal disease patterns in Iran.
Main Methods:
- Retrospective review of medical records and pathological diagnoses from native kidney biopsies over a 10-year period.
- Data collected included pathological diagnosis, clinical presentation, age at onset, gender, nephrotic proteinuria, hematuria, and hypertension.
- Correlation analysis between clinical findings and pathological diagnoses.
Main Results:
- Minimal-change disease was identified as the most prevalent glomerular disease.
- Nephrotic syndrome was the most common clinical presentation observed.
- Specific correlations between pathological diagnoses and clinical presentations were established for various glomerular diseases.
Conclusions:
- The study successfully described the spectrum of glomerular diseases in Iranian children based on kidney biopsy findings.
- Minimal-change disease and nephrotic syndrome represent key findings in this pediatric cohort.
- The correlations provide valuable information for diagnosing and managing glomerular diseases in children.
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