On the possible involvement of sulphomucopolysaccharides in the storage of catecholamines within the central nervous...

Rats treated at birth with 6-OH DA were sacrificed in adult age 24 h after an injection of 3H-NA. Synaptosomes were isolated from the cerebral cortex, the hypothalamus, the pons-medulla region and the cerebellum. The similar distribution pattern of 3H-NA and 35S on gradient centrifugation of the synaptosome preparations, the similar effect of 6-OHDA on the uptake of 3H-NA into slices of brain tissue in vitro and on their 35S content as well as the identification of chondroitin and heparan sulphate in the synaptosome fractions are observations which indicate a possible function of SMPSs in the storage of NA in adrenergic terminals.