The epidermis mitochondria ultrastructure evaluation of the etretinate-treated white rat

Etretinate belongs to the group of drugs known as retinoids which are vitamin A derivates. It is a representative of second-generation retinoids, i.e. a synthetic, aromatic analog of transretinoic acid. The administration of etretinate induces clinical effects and morphological alterations in the structure of both pathological and healthy epidermis in men and animals. The aim of the present work was to examine the influence of long-term various doses of etretinate (Tigason) treatment on the ultrastructural design of white Wistar rats epidermis mitochondria. The mitochondria turned out to be reacting to Tigason. The drug dose-dependent changes as well as the ultrastructural mitochondria design, and the degree of other ultrastructural reproductive epidermis layer alterations cell organelle were observed. The increase in the mitochondria number and size was noticed. We concluded that etretinate application modulates the ultrastructural status of the epithelial mitochondria, and the administered drug dose correlates with the mitochondria ultrastructural design changes and the degree of ultrastructural alterations in the other organelle of the epidermis reproductive-layer cells.