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Melatonin and cortisol secretion in patients with primary obsessive-compulsive disorder
F Catapano1, P Monteleone, A Fuschino
1Institute of Psychiatry, First Medical School, University of Naples, Italy.
Psychiatry Research
|December 1, 1992
Summary
Obsessive-compulsive disorder (OCD) patients show reduced 24-hour melatonin secretion but preserved circadian rhythm. Cortisol secretion is higher overall in OCD, with no change in its circadian pattern.
Area of Science:
- Neuroendocrinology
- Psychiatry
Background:
- Obsessive-compulsive disorder (OCD) is a mental health condition affecting millions globally.
- Disruptions in circadian rhythms and neuroendocrine function are implicated in psychiatric disorders.
Purpose of the Study:
- To investigate the 24-hour plasma levels of melatonin and cortisol in patients with primary obsessive-compulsive disorder (OCD).
- To compare neuroendocrine profiles between OCD patients and healthy controls.
Main Methods:
- Collected 24-hour plasma samples from seven OCD patients and seven matched healthy controls.
- Measured melatonin and cortisol concentrations over the 24-hour period.
- Analyzed circadian patterns and overall secretion levels.
Main Results:
- OCD patients exhibited significantly reduced 24-hour melatonin secretion compared to controls.
- The circadian rhythm of melatonin secretion was preserved in OCD patients.
- Cortisol secretion was elevated overall in OCD patients, but its circadian pattern remained unchanged.
- No significant correlation was observed between hormone levels and clinical symptoms of OCD.
Conclusions:
- Findings suggest altered melatonin and cortisol secretion patterns in individuals with OCD.
- These neuroendocrine differences may contribute to the pathophysiology of obsessive-compulsive disorder.
- Further research is warranted to explore the therapeutic implications of these hormonal changes.
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