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Immunolocalization of S100A2 calcium-binding protein in cartilage and bone cells

N Balmain1, F Moutahir, C W Heizmann

  • 1Laboratoire de Nutrition et de Sécurité Alimentaire-INRA, F-78350 Jouy-en-Josas, France. Nbalmain@aol.com

Cellular and Molecular Biology (Noisy-Le-Grand, France)
|August 6, 2003
PubMed

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Calmodulin-dependent Signaling01:16

Calmodulin-dependent Signaling

Calmodulin (CaM) is a calcium-binding protein in eukaryotes that controls various calcium-regulated cellular processes. It has four calcium-binding sites that bind calcium to form the calcium-calmodulin ( Ca2+-CaM) complex. GPCR stimulation increases the calcium levels in the cells that bind to CaM and induces a conformational change.
The Ca2+-CaM complex does not have enzymatic activity by itself. Instead, the complex binds downstream target proteins, including membrane proteins or enzymes,...