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BldD from Streptomyces coelicolor is a non-essential global regulator that binds its own promoter as a dimer
Marie A Elliot1, Troy R Locke, Claire M Galibois
1Department of Biological Sciences, CW405 Biological Sciences Building, University of Alberta, Edmonton, AB, Canada T6G 2E9.
FEMS Microbiology Letters
|August 6, 2003
Abstract:
We have shown that the bldD gene of Streptomyces coelicolor, while required for antibiotic production and morphological differentiation, is not essential for viability. We have also demonstrated that BldD forms a higher order complex both in solution and when bound to target DNA. Purified BldD exists in three forms in solution, as a tetramer, dimer and monomer, but only in the dimeric form when bound to its own promoter/operator.