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The role of dendritic cell subsets in immunity to viruses
Francis R Carbone1, William R Heath
1Department of Microbiology and Immunology, The University of Melbourne, Parkville, Victoria, Australia. fcarbone@unimelb.edu.au
Current Opinion in Immunology
|August 6, 2003
Abstract:
Dendritic cells orchestrate the adaptive immune response. As well as presenting MHC-restricted antigen for T-cell activation, they provide all the co-receptor signals required for full T-cell priming. As a consequence, they play a central role in the immune response to infections caused by many pathogenic agents, including viruses. In recent times, it has become apparent that dendritic cells represent a particularly heterogeneous population with individual subsets playing specialized roles in response to infection.