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Updated: Aug 8, 2026

A High Throughput MHC II Binding Assay for Quantitative Analysis of Peptide Epitopes
Published on: March 25, 2014
Epitope-based vaccines: an update on epitope identification, vaccine design and delivery
1La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA. alex@liai.org
Abstract:
The basic premise of the epitope-based approach to vaccine development is that, in certain cases, the responses induced by the natural immunogen are not optimal, and can be improved upon by isolation or optimization of specific components of the response. For example, immunodominance is a key factor limiting the type and breadth of adaptive immunity. Recent advances in understanding the mechanisms of immunodominance thus represent an opportunity to further develop the epitope-based approach.
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