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Updated: Sep 20, 2026

Application of Long-term cultured Interferon-γ Enzyme-linked Immunospot Assay for Assessing Effector and Memory T Cell Responses in Cattle
Published on: July 11, 2015
DNA vaccination: the answer to stable, protective T-cell memory?
Joanna R Kirman1, Robert A Seder
1Malaghan Institute of Medical Research, PO Box 7060, Wellington South, New Zealand. Jkirman@malaghan.org.nz
Abstract:
Distinct populations of both CD4(+) and CD8(+) memory T cells have been identified on the basis of their location (lymphoid versus non-lymphoid tissues) and function. There have been several recent advances in our understanding of the factors that govern the generation and maintenance of T-cell memory in vivo. Utilising this knowledge could contribute to the refinement of DNA vaccine technology to induce more robust and longer-lasting protective T-cell based immunity.
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