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[Significance and application of nuclear matrix protein 22 in detecting bladder cancer]
Abstract
Objective:
To investigate the significance of nuclear matrix protein 22 (NMP22) in the detection of bladder cancer.
Methods:
The level of NMP22 was measured in the urine of 90 patients (40 patients with bladder cancer and 50 patients with non-bladder cancer) by ELISA and compared with urinic cytology (UC).
Results:
The level of NMP22 in bladder cancer group was significantly higher than that of control group, and it was not influenced by hematuria. The sensitivity of NMP22 was high, but the specificity was lower than that of UC.
Conclusion:
NMP22 can be used to screen and follow up bladder cancer with high sensitivity.