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Updated: Aug 9, 2026
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Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
Published on: March 14, 2017
Recent developments in the anemia of chronic disease
1Hematology/Oncology Division, Medical University of South Carolina, 903 CSB, 96 Jonathan Lucas Street, Charleston, SC 29425, USA. meansr@musc.edu
Current Hematology Reports
|August 7, 2003
Summary
Anemia of chronic disease (ACD) involves low iron despite adequate stores, driven by inflammatory cytokines. New diagnostic tools and treatments like erythropoietin improve management of this common condition.
Area of Science:
- Hematology
- Immunology
- Pathophysiology
Background:
- Anemia of chronic disease (ACD) is a hypoproliferative anemia characterized by low serum iron with normal iron stores.
- ACD pathogenesis is linked to cytokines mediating immune and inflammatory responses.
- The clinical spectrum of ACD has broadened to include acute syndromes with similar mechanisms.
Purpose of the Study:
- To review advancements in understanding and managing anemia of chronic disease.
- To highlight improved diagnostic capabilities and therapeutic strategies for ACD.
Main Methods:
- Review of recent clinical and research findings on ACD.
- Analysis of diagnostic utility of soluble transferrin receptor.
- Evaluation of recombinant human erythropoietin in ACD management.
Main Results:
- Improved understanding of ACD's cytokine-driven mechanisms.
- Enhanced diagnostic accuracy using soluble transferrin receptor levels.
- Effective management strategies for severe ACD with erythropoietin.
Conclusions:
- ACD is a significant syndrome with expanding clinical relevance.
- Advances in diagnostics and therapeutics offer better patient outcomes.
- Ongoing research continues to clarify ACD pathogenesis.
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