Related Experiment Video

Updated: Sep 20, 2026

Simultaneous Quantification of Anti-vector and Anti-transgene-Specific CD8+ T Cells Via MHC I Tetramer Staining After Vaccination with a Viral Vector
08:10

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Published on: November 28, 2018

Polytope vaccines for the codelivery of multiple CD8 T-cell epitopes

Andreas Suhrbier1

  • 1Cooperative Research Center for Vaccine Technology, Queensland Institute of Medical Research, University of Queensland, Australia. andreasS@qimr.edu.au

Expert Review of Vaccines
|August 7, 2003
PubMed

Vaccines against a number of diseases, including HIV, Epstein Barr virus, malaria and several cancers, are believed to require the coinduction of multiple alphabeta CD8+ cytotoxic T-lymphocyte responses that are directed towards a number of different target antigens. The difficulties associated with making large recombinant vaccines that contain numerous antigens has led to the development of alphabeta CD8+ cytotoxic T-lymphocyte polyepitope or polytope vaccine approach, where multiple (usually 8-10 amino acids long) alphabeta CD8+ cytotoxic T-lymphocyte epitopes, derived from several antigens are conjoined into single artificial constructs. Such polytope constructs can be delivered using a number of different vaccine vector modalities with each epitope in the construct emerging as individually immunogenic.

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