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Methotrexate in acute persistent humoral rejection: an option for graft rescue
Fernando Bacal1, Gustavo L Sodré, Daniela A Fernandes
1Heart Failure Department, Heart Institute, University of São Paulo Medical School, São Paulo, Brazil. fbacal@uol.com.br
The Annals of Thoracic Surgery
|August 7, 2003
Abstract:
Humoral response emerges as an important component in acute graft rejection and a new challenge to clinicians in posttransplant care. Management of recurrent episodes and persistent activation of the humoral component of the immune system, despite the usual therapeutic approach to rejection, remains unknown. This article describes the successful use of methotrexate as an option for rescuing a graft in this worrisome situation.