Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Teaching cells new tricks.

Philippe Collas1, Anne-Mari Håkelien

  • 1Institute of Medical Biochemistry, University of Oslo, PO Box 1112 Blindern, 0317 Oslo, Norway. philippe.collas@basalmed.uio.no

Trends in Biotechnology
|August 7, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Multimodal epigenetic and enhancer network remodeling shape the transcriptional landscape of human beige adipocytes.

Communications biology·2026
Same author

Loss of multilevel 3D genome organization during breast cancer progression.

Genome research·2025
Same author

Transcriptional and Metabolic Changes Following Repeated Fasting and Refeeding of Adipose Stem Cells Highlight Adipose Tissue Resilience.

Nutrients·2025
Same author

Alternative isoform expression of key thermogenic genes in human beige adipocytes.

Frontiers in endocrinology·2024
Same author

Cytoskeletal rearrangement precedes nucleolar remodeling during adipogenesis.

Communications biology·2024
Same author

Loss of multi-level 3D genome organization during breast cancer progression.

bioRxiv : the preprint server for biology·2023
Same journal

Bacterial spores as a modular platform for the production of amyloids for materials.

Trends in biotechnology·2026
Same journal

The oriGen case and Mexico's regulatory blind spots in genomic biobanking.

Trends in biotechnology·2026
Same journal

A caspase-3-activated protein expression system for apoptosis visualization and apoptosis-pyroptosis conversion to boost antitumor activity.

Trends in biotechnology·2026
Same journal

Over 4 months of ethylene production using solid-state photosynthetic cell factories.

Trends in biotechnology·2026
Same journal

Closing the nitrogen loop in groundwater with biohybrid technologies.

Trends in biotechnology·2026
Same journal

Engineering environmental bacteria for whole-cell PET hydrolysis and assimilation.

Trends in biotechnology·2026
See all related articles

Transdifferentiation directly converts cell types, offering a promising method for generating patient-specific cells for regenerative medicine. Further research is needed to control epigenetic modifications for safe and effective cell replacement therapies.

Area of Science:

  • Cell biology
  • Regenerative medicine
  • Epigenetics

Background:

  • Transdifferentiation offers a pathway to create patient-specific cells for therapeutic applications.
  • Adult stem cells possess broader differentiation potential than previously understood.
  • Current transdifferentiation methods include nuclear transplantation and gene expression manipulation.

Purpose of the Study:

  • To explore the potential of direct cell type conversion for generating isogenic replacement cells.
  • To review recent advances in transdifferentiation techniques.
  • To highlight the need for controlled epigenetic modifications in nuclear reprogramming.

Main Methods:

  • Review of recent advances in transdifferentiation.
  • Discussion of techniques such as nuclear transplantation, cell culture manipulation, ectopic gene expression, and molecular uptake.

Related Experiment Videos

  • Emphasis on the importance of epigenetic modifications.

    • Main Results:

    • Transdifferentiation enables the direct conversion of one cell type to another.
    • Various methods are advancing the field of cell reprogramming.
    • Controlled epigenetic modifications are crucial for stable reprogramming.

    Conclusions:

    • Direct cell conversion holds significant promise for regenerative medicine by enabling the creation of isogenic cells.
    • Further investigation into the molecular mechanisms of nuclear reprogramming and epigenetic stability is essential.
    • Controlled and heritable epigenetic modifications are key to preventing unpredictable tissue changes.