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Related Experiment Videos

Risperidone-associated hyperprolactinemia: evaluation in twenty psychiatric outpatients.

Sandra Brunelleschi1, Patrizia Zeppegno, Francesco Risso

  • 1Department of Medical Sciences, School of Medicine, University of Piemonte Orientale "A. Avogadro", Via Solaroli, 17-28100 Novara, Italy. sandra.brunelleschi@med.unipmn.it

Pharmacological Research
|August 7, 2003
PubMed
Summary

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Risperidone, an atypical antipsychotic, significantly increased prolactin levels in 65% of outpatients. While hyperprolactinemia was common, prolactin-related side effects like reduced libido were less frequent.

Area of Science:

  • Psychiatry
  • Endocrinology
  • Pharmacology

Background:

  • Atypical antipsychotics, while lacking extrapyramidal side effects, can elevate prolactin levels similar to conventional neuroleptics.
  • Hyperprolactinemia is a known concern with certain antipsychotic medications.

Purpose of the Study:

  • To evaluate the impact of risperidone on serum prolactin levels.
  • To assess prolactin-related adverse effects in outpatients receiving risperidone.

Main Methods:

  • Observational study involving 20 outpatients at an Italian community psychiatric service.
  • Patients received risperidone (2-8 mg/day).
  • Serum prolactin levels and adverse effects were monitored.

Main Results:

Related Experiment Videos

  • Elevated prolactin levels were observed in 13 out of 20 patients (65%).
  • Eight patients experienced prolactin-related adverse effects, most commonly reduced libido.
  • A correlation between age and prolactin levels was noted in pre-menopausal women.

Conclusions:

  • Risperidone treatment is associated with a high incidence of hyperprolactinemia in outpatients.
  • Prolactin-related adverse effects, though present, were less frequent than elevated prolactin levels.
  • No clear correlation was found between treatment duration, dosage, prolactin levels, and adverse effects.