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Related Experiment Videos

Sevelamer.

Jane Henderson1, Paul Altmann

  • 1Oxford Kidney Unit, Churchill Hospital, Oxford, UK.

Nephron. Clinical Practice
|August 7, 2003
PubMed
Summary

Hyperphosphataemia management in chronic renal failure traditionally uses calcium- or aluminium-based phosphate binders. This review examines sevelamer, a novel alternative, and its clinical evidence.

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Area of Science:

  • Nephrology
  • Pharmacology
  • Internal Medicine

Background:

  • Hyperphosphataemia is a common complication in chronic renal failure (CRF).
  • Traditional treatments involve calcium- and aluminium-based phosphate binders.
  • These traditional binders have associated complications and limitations.

Purpose of the Study:

  • To review the rationale and complications of traditional phosphate binders.
  • To introduce sevelamer as a novel non-calcium, non-aluminium phosphate binder.
  • To evaluate the clinical evidence supporting sevelamer's use in CRF patients.

Main Methods:

  • Literature review of existing studies on phosphate binders.
  • Analysis of sevelamer's mechanism of action and clinical trial data.
  • Comparison of sevelamer with traditional phosphate binders.

Main Results:

  • Traditional binders carry risks such as hypercalcemia and aluminium toxicity.
  • Sevelamer offers an alternative with a different safety profile.
  • Evidence supports sevelamer's efficacy in lowering phosphate levels.

Conclusions:

  • Sevelamer presents a viable alternative for managing hyperphosphataemia in CRF.
  • It may offer advantages over traditional binders by avoiding calcium and aluminium-related side effects.
  • Further research may elucidate optimal use in diverse patient populations.

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