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Related Experiment Videos

Functional brain mapping in freely moving rats during treadmill walking.

D P Holschneider1, J-M I Maarek, J Yang

  • 1Department of Psychiatry and the Behavioral Sciences, University of Southern California, Keck School of Medicine, Los Angeles, California, U.S.A. holschne@usc.edu

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
|August 7, 2003
PubMed
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An implantable microbolus infusion pump (MIP) enables functional neuroimaging in freely moving rats. This technology maps brain activity during locomotion, overcoming limitations of immobilized subjects.

Area of Science:

  • Neuroscience
  • Functional Neuroimaging
  • Animal Models

Background:

  • Immobilization in functional neuroimaging restricts behavioral studies.
  • Movement artifacts are a significant challenge in brain imaging.
  • Developing methods for imaging active, unrestrained subjects is crucial.

Purpose of the Study:

  • To evaluate an implantable microbolus infusion pump (MIP) for functional neuroimaging.
  • To assess the MIP's utility in freely moving rats during a locomotor task.
  • To map brain activity associated with locomotion in rats.

Main Methods:

  • Utilized an implantable microbolus infusion pump (MIP) for remote radiotracer injection.
  • Measured cerebral blood flow-related tissue radioactivity (CBF-TR) using [14C]-iodoantipyrine.

Related Experiment Videos

  • Employed an indicator-fractionation method followed by autoradiography in rats performing a treadmill task.

    • Main Results:

    • Locomotion on a treadmill significantly increased CBF-TR in motor circuits.
    • Specific brain regions showing increased activity include the motor cortex, striatum, thalamus, and cerebellum.
    • Somatosensory cortex and secondary visual cortex also exhibited heightened activity during locomotion.

    Conclusions:

    • Implantable microbolus infusion pumps (MIPs) are effective tools for functional neuroimaging in moving animals.
    • This technology facilitates the study of behaviors not possible in restrained subjects.
    • MIPs advance the capability to perform brain mapping during complex, naturalistic behaviors.