Related Experiment Video
Updated: Sep 20, 2026

Simple and Effective Procedure for Hemostasis in Mouse Arteries
Published on: November 28, 2025
Arterial puncture closure using a collagen plug, I. (Angio-Seal)
William S Rilling1, Matthew Dicker
1Section of Vascular/Interventional Radiology, Medical College of Wisconsin, Froedtert Memorial Lutheran Hospital, Milwaukee, WI 53226, USA.
Abstract:
Closure devices can generally be categorized by their mechanism of obtaining hemostasis. Currently, devices are either suture-based, collagen-based, or utilize a combination of technologies. They can also be classified on the basis of whether or not they have an intravascular component or exclusively extra-vascular components. The devices that are currently available differ markedly in their mechanism of action, deployment, advantages, and disadvantages. In this article, we will review in detail the Angio-Seal closure device, review some of the current literature regarding this device, and assess its complications, advantages, and disadvantages.
More Related Videos
Related Concept Videos
Aneurysm III: Interprofessional Care
Formation of the Platelet Plug
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...

