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[The association between glucocorticoid receptor gene G1666T polymorphism and cerebral infarction in Chinese]
Lan-qin Chi1, Chen Zhang, Bing Luo
1Department of Neurology, Laiyang Central Hospital, Yantai, Shandong, 265200 PR China. LINZHIXD@public.ytptt.sd.cn
Objective:
To ascertain whether the human glucocorticoid receptor (GR) gene polymorphism is associated with cerebral infarction (CI) and essential hypertension (EH) in Chinese.
Methods:
This is a case-control study of Chinese DNA samples abstracted from 163 subjects. The samples were analysed by a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) to determine the intron 4 variant of human GR gene.
Results:
By analysis of the samples from both sexes as a whole, no association was observed between the EH+CI group and control group, and between the CI group and control group. However, by analysis of the samples from the females, weak association was observed between the EH+CI group and control group, and between the CI group and control group; the frequency of allele G was 0.64 for the EH+CI group, 0.69 for CI group and 0.46 for control group.
Conclusion:
The G allele may be a predisposing gene marker, GR gene intron 4 polymorphism contributes to the development of CI in females.
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