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[Hypoglycemia in diabetes mellitus].

K Irsigler1

  • 1III. Medizinischen Abteilung, Stoffwechselkrankheiten und Nephrologie und Ludwig-Boltzmann-Institut für Stoffwechselerkrankugen und Ernährung, Krankenhaus Wien-Lainz.

Acta Medica Austriaca
|January 1, 1992
PubMed
Summary

Type 1 diabetes patients frequently experience hypoglycemia, with severe episodes leading to coma or death. Sulfonylurea-treated patients have a much lower risk of hypoglycemia, highlighting the need for preventive strategies.

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Area of Science:

  • Endocrinology
  • Metabolic Diseases
  • Diabetes Mellitus Research

Context:

  • Type 1 diabetes (T1D) patients frequently experience symptomatic hypoglycemia, with significant morbidity and mortality.
  • Insulin therapy in T1D is associated with a high incidence of hypoglycemia, including severe attacks and fatalities.
  • Sulfonylurea treatment shows a considerably lower incidence of hypoglycemia compared to insulin in diabetic patients.

Purpose:

  • To analyze the incidence and risks of symptomatic hypoglycemia in Type 1 diabetic patients.
  • To compare the risks of hypoglycemia between insulin-treated and sulfonylurea-treated patients.
  • To emphasize the importance of preventive measures against hypoglycemia in diabetes management.

Summary:

  • Symptomatic hypoglycemia occurs 1-2 times weekly in Type 1 diabetic patients.
  • 30% of insulin-treated patients experience hypoglycemic coma in their lifetime; 3-4% die from hypoglycemia.
  • Sulfonylurea-treated patients have a hypoglycemia incidence of 0.2 per 1000 patient-years, with 8% mortality from severe attacks.

Impact:

  • Highlights the substantial risks of hypoglycemia associated with insulin therapy in Type 1 diabetes.
  • Underscores the lower hypoglycemia risk with sulfonylurea treatment.
  • Stresses the critical need for preventive strategies to mitigate hypoglycemia risks in diabetes care.

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