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[Prevention and release of epidural-morphine-induced urinary retention with phenoxybenzamine and neostigmine]
1Department of Anesthesiology, the 4th Hospital of Zhenjiang, Zhenjiang 212001, China. tpopo@yeah.net
Objective:
To study the effects of preoperative phenoxybenzamine (o.p) on preventing epidural-morphine-induced urinary retention and effects of neostigmine on releasing it.
Methods:
80 patients who received epidural morphine to release postoperative pain were divided into 4 groups randomly and received preoperative phenoxybenzamine (group P, n = 20), neostigmine (i. m) when urinary retention happened (group N, n = 20), both drugs (group U, n = 20), and without drugs (Control, n = 20), respectively. The incidences of urinary retention and release were observed.
Results:
No significant decrease (P > 0.05) happened after operation in the incidence of epidural-morphine-induced urinary retention both in the group P and in the group N. Neostigmine(i. m) could significantly release (P < 0.001) the epidural-morphine-induced urinary retention when phenoxybenzamine was administrated preoperatively.
Conclusion:
Preoperative phenoxybenzamine can not prevent epidural-morphine-induced urinary retention. Neostigmine can release the urinary retention only when preoperative phenoxybenzamine is used.
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