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Updated: Sep 20, 2026
Pseudomonas aeruginosa Induced Lung Injury Model
Published on: October 29, 2014
[Changes of plasma nitric oxide and tumor necrosis factor-alpha in lung elastase injury induced inflammatory response
1Department of Physiology, Institute of Basic Medical Science, CAMS, PUMC, Beijing 100005, China. Lxyw315@ns.cetin.net.cn
Objective:
To investigate the role of the NO and TNF-alpha in lung elastase injury induced inflammatory response of hamster.
Methods:
Lung elastase injury induced inflammatory hamster model was established. NOS activity in airway epithelial cells and lung monocytes/macrophage, as well as the serum content of NO and TNF-alpha were measured respectively.
Results:
The results indicated that iNOS activity in epithelium and monocytes/macrophages were significantly enhanced. In the early period of inflammation the NO and TNF-alpha content in serum increased obviously and maintained in a high level (P < 0.001).
Conclusions:
This Study suggested that both NO and TNF-alpha are important mediators participating in the lung elastase injury-induced inflammatory response. Our data suggested NO might play a regulatory role in the release of TNF-alpha.
