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Related Experiment Videos

Oesophageal acid stimulation in humans: does it alter baroreflex function?

Eva Zöllei1, Dóra Paprika, T Wittmann

  • 1Medical Intensive Care Unit, Cardiology Center, Faculty of Medicine, University of Szeged, Szeged, Hungary. zollei@hotmail.com

Acta Physiologica Hungarica
|August 9, 2003
PubMed
Summary

Esophageal acid stimulation reduced heart rate variability in gastro-esophageal reflux disease patients. However, acid infusion did not affect blood pressure variability or baroreflex gain in either patients or controls.

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Area of Science:

  • Cardiology
  • Gastroenterology
  • Autonomic Nervous System Function

Background:

  • Gastro-esophageal reflux disease (GERD) is common.
  • The impact of esophageal acid on cardiovascular autonomic function is not fully understood.
  • The Bernstein test assesses esophageal sensitivity to acid.

Purpose of the Study:

  • To investigate the effect of esophageal acid stimulation on heart rate variability (HRV), blood pressure variability (BPV), and baroreflex gain.
  • To compare cardiovascular responses between GERD patients and healthy controls during acid exposure.

Main Methods:

  • 10 GERD patients and 10 controls underwent esophageal instillation of saline and hydrochloric acid.
  • Heart rate and blood pressure variability indices were analyzed using time-domain, frequency-domain, and cross-spectral analysis.

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  • Baroreflex gain was assessed using linear spontaneous sequence and cross-spectral methods.

    • Main Results:

    • In GERD patients, esophageal acid significantly reduced standard deviation of RR intervals (SDRR) and root mean square of successive differences (RMSSD), indicating decreased HRV.
    • High-frequency power of RR intervals tended to decrease during acid infusion in GERD patients (p=0.055).
    • No significant changes in BPV or baroreflex gain were observed in either group during acid or saline infusions.

    Conclusions:

    • Esophageal acid stimulation can acutely decrease heart rate variability in patients with GERD.
    • Autonomic cardiovascular regulation, specifically baroreflex sensitivity, remains unaltered during esophageal acid exposure.
    • These findings suggest a localized effect of esophageal acid on cardiac autonomic control in GERD patients.