Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Antidepressant-induced hepatotoxicity.

M Isabel Lucena1, Alfonso Carvajal, Raúl J Andrade

  • 1Instituto de Farmacoepidemiología de la Universidad de Valladolid, Spain.

Expert Opinion on Drug Safety
|August 9, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Systematic review on genetic polymorphisms associated with idiosyncratic drug-induced liver injury (iDILI): iDILInet as an interactive visualization tool.

Acta pharmaceutica Sinica. B·2026
Same author

Steatotic Liver Disease at Primary Biliary Cholangitis Diagnosis: Association With Ursodeoxycholic Acid Response and Outcomes.

Liver international : official journal of the International Association for the Study of the Liver·2026
Same author

HLA-B*44 Alleles and HLA-DQA1*03:01 as Genetic Risk Factors for Drug-Induced Liver Injury due to Fluoroquinolones.

Liver international : official journal of the International Association for the Study of the Liver·2026
Same author

An update on drug-induced liver injury-What's new?

Journal of internal medicine·2026
Same author

Comparative Pharmacological Profiling of Psychotherapeutic Drugs Reveals a Functional Taxonomy Based on Direct Inhibition of Smooth Muscle Excitability.

Pharmaceuticals (Basel, Switzerland)·2026
Same author

Seronegative Autoimmune Hepatitis in Adults Is a Rare Entity Often Obscured by Suboptimal Diagnostic Assessment.

Liver international : official journal of the International Association for the Study of the Liver·2026
Same journal

Could anticholinergics accelerate ALS progression? A critical perspective on drug safety and disease vulnerability.

Expert opinion on drug safety·2026
Same journal

Safety profile of teprotumumab-trbw, the first and only FDA-approved treatment for thyroid-associated ophthalmopathy.

Expert opinion on drug safety·2026
Same journal

A systematic review and meta-analysis of safety and efficacy parameters of sotatercept in the therapy of pulmonary arterial hypertension.

Expert opinion on drug safety·2026
Same journal

Tirzepatide data: safety first is safety always!

Expert opinion on drug safety·2026
Same journal

An update on the safety of biologics for the treatment of psoriasis.

Expert opinion on drug safety·2026
Same journal

Recent advances in trastuzumab and its antibody-drug conjugates-related liver injury.

Expert opinion on drug safety·2026
See all related articles

Antidepressant medications can cause liver damage, ranging from mild enzyme increases to severe liver failure. Older antidepressants like MAOIs and TCAs pose a higher risk than newer SSRIs, with nefazodone noted for severe hepatotoxicity.

Area of Science:

  • Pharmacology
  • Hepatology
  • Psychiatry

Background:

  • Depression is a prevalent, chronic illness with significant health impacts.
  • Antidepressants are primary treatments but carry risks, including liver toxicity (hepatotoxicity).
  • Understanding antidepressant-induced hepatotoxicity is crucial for patient safety.

Purpose of the Study:

  • To review the risk of liver toxicity associated with major antidepressant drugs.
  • To analyze the relationship between chemical structures and hepatotoxicity mechanisms.
  • To discuss clinical manifestations and prevention strategies for antidepressant-induced liver injury.

Main Methods:

  • Literature review focusing on structural criteria of antidepressants.
  • Analysis of underlying mechanisms and chemical structures involved in hepatotoxicity.

Related Experiment Videos

  • Examination of clinicopathological expressions of liver damage.

    • Main Results:

    • Antidepressant-induced hepatotoxicity ranges from elevated liver enzymes to fulminant liver failure.
    • Classical antidepressants (MAOIs, TCAs) show a higher potential for liver damage compared to newer SSRIs.
    • Nefazodone is highlighted for its potential for severe hepatotoxicity.

    Conclusions:

    • Different antidepressant classes exhibit varying risks of hepatotoxicity.
    • Structural characteristics and mechanisms play a role in drug-induced liver injury.
    • Guidelines for managing and preventing antidepressant-induced hepatotoxicity are essential.