Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Zyban-- is there a cause for concern?

Joseph A Tracey

    Expert Opinion on Drug Safety
    |August 9, 2003
    PubMed
    Summary

    Bupropion hydrochloride aids smoking cessation for about 20% of users, potentially improving with nicotine replacement therapy. The study weighs these health benefits against risks like insomnia and seizures.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Accurate Measurement of First Metatarsophalangeal Range of Motion in Patients With Hallux Rigidus.

    Foot & ankle international·2015
    Same author

    The epidemiology and type of medication errors reported to the National Poisons Information Centre of Ireland.

    Clinical toxicology (Philadelphia, Pa.)·2011
    Same author

    Mushroom poisoning in Ireland: the collaboration between the National Poisons Information Centre and expert mycologists.

    Clinical toxicology (Philadelphia, Pa.)·2011
    Same author

    The availability of toxicological analyses for poisoned patients in Ireland.

    Clinical toxicology (Philadelphia, Pa.)·2010
    Same author

    Cardiac arrest following therapeutic administration of N-acetylcysteine for paracetamol overdose.

    Clinical toxicology (Philadelphia, Pa.)·2008

    Area of Science:

    • Pharmacology
    • Public Health
    • Addiction Medicine

    Background:

    • Bupropion hydrochloride, a monocyclic antidepressant, is utilized in a slow-release formulation for smoking cessation.
    • Common side effects include insomnia and dry mouth, with a seizure risk of approximately 1 in 1000 patients.

    Discussion:

    • Overdosing on bupropion hydrochloride can lead to serious cardiovascular and neurological symptoms, including tachycardia, conduction defects, and convulsions.
    • The efficacy of bupropion hydrochloride for smoking cessation is around 20%, with potential enhancement through combination with nicotine replacement therapy.

    Key Insights:

    • Bupropion hydrochloride demonstrates moderate effectiveness in aiding individuals to quit smoking.
    • Combining bupropion hydrochloride with nicotine replacement therapy may offer synergistic benefits for smoking cessation.
    • The therapeutic value of bupropion hydrochloride must be carefully balanced against its associated risks, particularly in overdose scenarios.

    Outlook:

    • Further research could explore optimizing bupropion hydrochloride dosages and combinations for enhanced smoking cessation success rates.
    • Investigating long-term safety profiles and risk-benefit analyses in diverse patient populations is crucial.
    • Developing novel therapeutic strategies that build upon bupropion hydrochloride's mechanisms of action could advance addiction treatment.

    Related Experiment Videos