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A new system to target the effect-site during propofol sedation
A G Doufas1, M Bakhshandeh, A R Bjorksten
1OUTCOMES RESEARCH Institute and Department of Anesthesiology and Pharmacology, University of Louisville, Louisville, KY 40202, USA. agdoufas@louisville.edu
Acta Anaesthesiologica Scandinavica
|August 9, 2003
Summary
This study shows a new target-controlled infusion system for propofol sedation is accurate and stable. The system effectively targets effect-site concentrations for safe and reliable anesthesia.
Area of Science:
- Anesthesiology
- Pharmacology
- Medical Devices
Background:
- Evaluated a novel integrated, covariate-adjusted, target-controlled infusion (TCI) system.
- Tested during sedation with propofol, alone or combined with nitrous oxide (N2O).
Purpose of the Study:
- To assess the accuracy and stability of a new TCI system for propofol.
- To determine its performance in targeting effect-site concentrations during sedation.
Main Methods:
- Employed sequential 15-minute cycles in 20 volunteers.
- Propofol infusion adjusted to target effect-site concentrations until loss of consciousness (OAA/S score = 2).
- Compared performance with and without 50% N2O.
Main Results:
- Minimal difference in venous plasma propofol concentrations between cycle start and end.
- No significant differences in Observer's Assessment Alertness/Sedation (OAA/S) scores or bispectral index.
- Median performance errors were clinically acceptable, with low divergence and wobble.
Conclusions:
- The TCI system demonstrated clinically acceptable accuracy and stability.
- The covariate-adjusted pharmacokinetic model effectively targets effect-site concentrations for propofol sedation.