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Measurement of the Pressure-volume Curve in Mouse Lungs
09:49

Measurement of the Pressure-volume Curve in Mouse Lungs

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Progressive decline in plethysmographic lung volumes in infants: physiology or technology?

Georg Hülskamp1, Ah-fong Hoo, Henrik Ljungberg

  • 1Portex Anaesthesia, Intensive Therapy and Respiratory Medicine Unit, Institute of Child Health and Great Ormond Street Hospital for Children NHS Trust, London, UK. g.hulskamp@ich.ucl.ac.uk

American Journal of Respiratory and Critical Care Medicine
|August 9, 2003
PubMed

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Respiratory volumes are crucial metrics, meticulously measured to quantify the air exchanged in and out of the lungs during various phases of the breathing cycle. These precise measurements are vital for assessing lung function, diagnosing respiratory conditions, and monitoring overall respiratory health. Each parameter provides specific insights into the mechanics of breathing and the functional capacity of the lungs.
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Pressure Relationships in Thoracic Cavity

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Factors Affecting Pulmonary Ventilation

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Atelectasis develops when alveoli lose their air and collapse inward. Because lung tissue is naturally elastic, these air sacs shrink rather than remaining open. Collapsed alveoli are no longer ventilated, reducing their role in gas exchange. Blood flow may continue in these regions, creating a ventilation–perfusion mismatch. Clinical findings include decreased breath sounds, dullness to percussion, reduced chest expansion, and decreased tactile fremitus as sound transmission through collapsed...