Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Evidence-based clinical practice].

Christian Gluud1

  • 1Cochrane Hepato-Biliary Group, Copenhagen Trial Unit, Centre for Clinical Intervention Research, H:S Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark. cgluud@ctu.rh.dk

Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
|August 9, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effects of primary or secondary prevention with vitamin A supplementation on clinically important outcomes: a systematic review of randomised clinical trials with meta-analysis and trial sequential analysis.

BMJ open·2024
Same author

WHO Essential Medicines List and methylphenidate for ADHD in children and adolescents.

The lancet. Psychiatry·2024
Same author

Concentrations, Number of Doses, and Formulations of Aluminium Adjuvants in Vaccines: A Systematic Review with Meta-Analysis and Trial Sequential Analysis of Randomized Clinical Trials.

Vaccines·2023
Same author

Ugeskrift for laeger·2023
Same author

Detailed statistical analysis plan for a secondary Bayesian analysis of the SafeBoosC-III trial: a multinational, randomised clinical trial assessing treatment guided by cerebral oximetry monitoring versus usual care in extremely preterm infants.

Trials·2023
Same author

The effects of cerebral oximetry in mechanically ventilated newborns: a protocol for the SafeBoosC-IIIv randomised clinical trial.

Trials·2023
Same journal

Splenic Angiosarcoma Misdiagnosed as PrimaryMyelofibrosis: Report of Two Cases and a Literature Review.

Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae·2026
Same journal

Anesthetic Management for Epicardial Pacemaker Implantation in An Adult Patient With Uncorrected Functional Single Ventricle:A Case Report.

Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae·2026
Same journal

Magnetic Resonance Imaging Combined With Ultrasonography for Early Diagnosis of Complete Hydatidiform Mole With Coexisting Fetus: Report of One Case.

Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae·2026
Same journal

Prospects for China's Pharmaceutical Industry Development During the 15th Five-Year Plan Period.

Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae·2026
Same journal

[Comparison of Imaging Efficacy and Patient Tolerability Between a Novel Cellulose-Based anda Conventional Starch-Based Oral Contrast Agent: A Prospective Randomized Controlled Trial].

Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae·2026
Same journal

[Application Value of Super-Resolution Ultrasound Imaging in the Diagnosisof American College of Radiology Thyroid Imaging Reporting and Data System Category 4 and 5 Thyroid Nodules].

Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae·2026
See all related articles

Randomized clinical trials often overestimate intervention effects due to methodological flaws. Improving trial quality and adherence to evidence-based medicine principles is crucial for reliable healthcare.

Area of Science:

  • Clinical Research Methodology
  • Evidence-Based Medicine

Background:

  • Randomized clinical trials (RCTs) are the gold standard for evaluating healthcare interventions.
  • Methodological weaknesses in RCTs, including inadequate randomization, allocation concealment, and blinding, can lead to significant overestimation of intervention effects (average ~50%).

Discussion:

  • Non-adherence to the intention-to-treat (ITT) analysis method also inflates intervention effect estimates.
  • Over 90% of RCTs exhibit these critical methodological deficiencies, contributing to variability in clinical practice.

Key Insights:

  • Inadequate randomization, allocation concealment, and blinding are prevalent issues in RCTs.
  • Failure to use intention-to-treat analysis is common and biases results.
  • Methodological flaws in RCTs lead to overestimated intervention effects, impacting evidence-based medicine.

Related Experiment Videos

Outlook:

  • Implementing guidelines like Good Clinical Practice and the CONSORT Statement can improve trial quality.
  • Promoting multicenter trials, The Cochrane Collaboration, and investment in education and applied research are vital.
  • Strengthening evidence-based medicine requires enhanced research integrity and application.