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[Screening by maternal serum markers for Down's syndrome].

Jun-tao Liu1, Na Hao, Nian-hu Sun

  • 1Department of Gynecology and Obstetrics, PUMC Hospital, CAMS, PUMC, Beijing 100730, China.

Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
|August 9, 2003
PubMed
Summary

Maternal serum screening effectively detects Down

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Area of Science:

  • Prenatal diagnostics
  • Biochemical markers in pregnancy

Context:

  • Screening for Down's syndrome (DS) is crucial for early intervention.
  • Maternal serum markers are widely used for prenatal screening.

Purpose:

  • To evaluate the effectiveness of different maternal serum markers for Down's syndrome screening.
  • To determine the optimal combination of markers for early and mid-pregnancy screening.

Summary:

  • The study utilized Alpha-fetoprotein (AFP), free beta-human chorionic gonadotrophin (free beta-HCG), and pregnancy-associated plasma protein A (PAPP-A) in maternal serum screening.
  • A detection rate of 3.8% for Down's syndrome was achieved, with a 5% false positive rate using triple markers (AFP, free beta-HCG, PAPP-A).
  • Pregnancy-associated plasma protein A (PAPP-A) showed promise as an early marker, while AFP and free beta-HCG are useful for detecting fetal abnormalities.

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Impact:

  • This research supports shifting prenatal diagnostic procedures to an earlier stage of pregnancy.
  • The findings contribute to optimizing Down's syndrome screening protocols.
  • Improved screening methods can lead to earlier diagnosis and management of Down's syndrome.