Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Essential Minerals for Bone Health01:31

Essential Minerals for Bone Health

The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Skeleton and Calcium Homeostasis01:21

Skeleton and Calcium Homeostasis

Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Vitamins01:30

Vitamins

Vitamins, derived from the Latin word for life, are essential organic substances required in small quantities for optimal growth and overall well-being. Unlike other organic nutrients, vitamins don't act as sources of energy or building materials but rather facilitate these nutrients' utilization by the body. Vitamins are predominantly coenzymes, assisting enzymes in specific chemical actions, like the oxidation of glucose for energy involving B vitamins. Most vitamins are not produced in our...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Radiation cross-linked collagen/dextran dermal scaffolds: effects of dextran on cross-linking and degradation.

Journal of biomaterials science. Polymer edition·2014
Same author

Hexagonal Ag nanoarrays induced enhancement of blue light emission from amorphous oxidized silicon nitride via localized surface plasmon coupling.

Optics express·2014
Same author

The gene expression patterns of BMPR2, EP300, TGFβ2, and TNFAIP3 in B-Lymphoma cells.

Cancer biology & medicine·2014
Same author

[Therapeutic effect of vildagliptin and insulin aspart injection in elderly patients with type 2 diabetes].

Nan fang yi ke da xue xue bao = Journal of Southern Medical University·2014
Same author

[Evaluation and indication of human epithelial growth factor receptor 2 status in breast carcinoma with amplified chromosome].

Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences·2014
Same author

Thiol-assisted one-pot synthesis of peptide/protein C-terminal thioacids from peptide/protein hydrazides at neutral conditions.

Organic & biomolecular chemistry·2014

Related Experiment Video

Updated: Jul 5, 2026

Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model
07:12

Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model

Published on: September 28, 2017

[Vitamin K and osteoporosis].

Lin-zhi Luo1, Ling Xu

  • 1Department of Scientific Research, PUMC Hospital, CAMS, PUMC, Beijing 100730, China.

Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
|August 9, 2003
PubMed
Summary

Vitamin K plays a crucial role in bone health by aiding bone formation and inhibiting bone mass absorption. Studies show vitamin K supplementation increases bone mineral density and reduces fracture rates in osteoporosis patients.

Area of Science:

  • Biochemistry
  • Bone Metabolism
  • Nutritional Science

Context:

  • Osteoporosis is a significant global health concern characterized by low bone mass and increased fracture risk.
  • Vitamin K's role in bone metabolism has been increasingly recognized, particularly its function as a cofactor in carboxylation reactions essential for bone health.

Purpose:

  • To elucidate the multifaceted roles of vitamin K in bone metabolism and its potential therapeutic applications in osteoporosis.
  • To review current evidence on vitamin K's impact on bone mineral density and fracture rates.

Summary:

  • Vitamin K acts as a cofactor for carboxylase, facilitating the gamma-carboxylation of osteocalcin, which is critical for bone formation and mineralization.
  • It influences calcium balance and bone metabolism by affecting the synthesis and excretion of nephrocalcin and interleukins (IL-1, IL-6).

More Related Videos

Isolation of Mesenchymal Stem Cells from Human Alveolar Periosteum and Effects of Vitamin D on Osteogenic Activity of Periosteum-derived Cells
06:47

Isolation of Mesenchymal Stem Cells from Human Alveolar Periosteum and Effects of Vitamin D on Osteogenic Activity of Periosteum-derived Cells

Published on: May 4, 2018

Preparation Of Gushukang (GSK) Granules for In Vivo and In Vitro Experiments
06:16

Preparation Of Gushukang (GSK) Granules for In Vivo and In Vitro Experiments

Published on: May 9, 2019

Related Experiment Videos

Last Updated: Jul 5, 2026

Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model
07:12

Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model

Published on: September 28, 2017

Isolation of Mesenchymal Stem Cells from Human Alveolar Periosteum and Effects of Vitamin D on Osteogenic Activity of Periosteum-derived Cells
06:47

Isolation of Mesenchymal Stem Cells from Human Alveolar Periosteum and Effects of Vitamin D on Osteogenic Activity of Periosteum-derived Cells

Published on: May 4, 2018

Preparation Of Gushukang (GSK) Granules for In Vivo and In Vitro Experiments
06:16

Preparation Of Gushukang (GSK) Granules for In Vivo and In Vitro Experiments

Published on: May 9, 2019

  • Epidemiological and intervention studies consistently demonstrate that vitamin K intake increases bone mineral density and reduces fracture incidence in individuals with osteoporosis.

    • Impact:

    • Vitamin K supplementation shows promise in improving bone health and reducing fracture risk, suggesting its potential as a therapeutic agent for osteoporosis.
    • Further research is warranted to establish optimal dosages and long-term efficacy before widespread clinical application.
    • Recent increases in dietary reference intakes for vitamin K by the American Medical Association highlight its growing importance in public health recommendations.