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[Study of the gene expression pattern in the Kkay mouse with type 2 diabetes by genomic-scale gene expression
Qing-hua Guo1, Ju-ming Lu, Ling Yin
1Endocrinology Department, General Hospital of PLA, Beijing 100853, China.
Objective:
To study the genes differentially expressed in the liver of Kkay diabetic and normal mice by genomic-scale gene expression analysis.
Methods:
cDNA microarray chips containing 8,192 cDNAs were used to explore the gene expression pattern of Kkay mouse liver.
Results:
One hundred and fifty-four genes were screened out, including 68 complete cDNAs and expressed sequence tags, and among them 40 genes were up-regulated and 114 genes were down-regulated respectively.
Conclusion:
Most of the gene expression analysis results were consistent with previous study, and the gene expression pattern of Kkay mouse based on cDNA microarray could be used for high-throughout screening out the genes associated with type 2 diabetes.