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Updated: Sep 20, 2026
A Revised Surgical Approach to Induce Endolymphatic Hydrops in the Guinea Pig
Published on: June 4, 2020
[Endolymphatic hydrops of both ears of guinea pig produced by aldosterone]
Zi-dong Jiang1, Lian-shan Zhang
1Department of Otolaryngology, PUMC Hospital, CAMS, PUMC, Beijing 100730, China. zidongjiangcn@yahoo.com.cn
Objective:
To develop endolymphatic hydrops in both ears of guinea pigs by aldosterone.
Methods:
Thirty animals were divided into 3 groups with 10 in each group. Group A received left ears operation following Kimura', with right ears non-operated as control; group B received introperitonal injection of aldosterone (0.1 mg.0.1 kg-1.d-1) for continuous 5 days; group C received introperitonal injection of 0.5 ml 0.9% NS. Five out of group A,B and C were killed 1 month and 2 months later respectively for analysis of blood K+, Ca2+, Na+ and pathological examination of inner ear, heart, lung, brain, liver and kidney.
Results:
In group A' moderate to severe endolymphatic hydrops developed in the operated ears during 1 and 2 months. In group B, mild endolymphatic hydrops developed in the both ears during 1 month, and within 2 months it was moderate and severe. No endolymphatic hydrops developed in group C. In contrast to group C, No significant changes could be found in blood analysis of group A, but the concentrations of K+ and Ca2+ were declined, and that of Na+ were increased in group B. The heart, lung, brain, liver, and kidney of all animals were normal.
Conclusions:
Aldosterone may induce endolymphatic hydrops in both ears.
