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Updated: Sep 20, 2026
Optogenetic Stimulation of the Auditory Nerve
Published on: October 8, 2014
[An approach for proper recording of the unit discharge in auditory nerve and inferior colliculus]
Objective:
To explore a proper recording of the unit discharge in auditory nerve and inferior colliculus for the observation of characteristics of response potential.
Methods:
Single unit discharge in auditory nerve and inferior colliculus of healthy adult cat to acoustic stimulation and intracochlear electrical stimulation were recorded. With glass microelectrode.
Results:
(1) the spontaneous discharge in auditory nerve primary fibers were identified. (2) The waveform of the spontaneous discharge in auditory nerve primary fibers was biphasic potential with positive pulse width 0.5 ms. (3) The discharge rate of auditory nerve ranged from several PPS to 100PPS. (4) The response in inferior colliculus to high frequency pure tone stimulation lacked phase locking. (5) The response in inferior colliculus to low frequency electrical stimulation in cochlea showed phase locking.
Conclusions:
It was successful to record the spontaneous discharges and auditory evoked responses in auditory nerve as well as the pure tone evoked response and electrically evoked response in inferior colliculus. However, the existing technical problem in recording the electrically evoked response in auditory nerve was to keep the response potential stable.
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