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Updated: Aug 11, 2026

Killer Artificial Antigen Presenting Cells (KaAPC) for Efficient In Vitro Depletion of Human Antigen-specific T Cells
Published on: August 12, 2014
[Survivin--a new tumor-specific anti-apoptosis factor]
1Department of Pathology, PUMC Hospital, CAMS, PUMC, Beijing 100730, China. guanjianpumch@sina.com
Survivin (SVV), an inhibitor of apoptosis protein, is reexpressed in tumors and promotes cell survival. Its tumor-specific expression suggests it is a promising target for novel cancer therapies.
Area of Science:
- Biochemistry
- Molecular Biology
- Oncology
Background:
- Survivin (SVV) is a member of the inhibitor of apoptosis (IAP) protein family.
- SVV inhibits apoptosis induced by various factors and is crucial for cell division.
- It is expressed during embryonic development but typically absent in adult tissues.
Purpose of the Study:
- To investigate the role of Survivin (SVV) in cancer.
- To explore SVV as a potential therapeutic target for tumors.
Main Methods:
- Analysis of Survivin (SVV) expression patterns.
- Review of existing studies on SVV function and expression in tumors.
Main Results:
- Survivin (SVV) is reexpressed in transformed cell lines and human tumors.
- Overexpression of SVV is associated with tumor prognosis.
- SVV contributes to chemotherapy resistance in tumor cells.
Conclusions:
- Survivin (SVV) acts as a tumor-specific anti-apoptosis factor.
- SVV is a potential target for gene- and protein-based cancer therapies.
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