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Updated: Aug 1, 2026
Ex Vivo Corneal Organ Culture Model for Wound Healing Studies
Published on: February 15, 2019
[Effect of recombinant epidermal growth factor on corneal epithelial cells after excision of pterygium]
1Department of Ophthalmology, Beijing Friendship Hospital, Beijing 100050, China.
Objective:
To investigate the effects of recombinant epidermal growth factor on the wounded corneal healing after excision of pterygium.
Methods:
Simple and unrecurrent pterygium was selected, excised and sewed up conjunctival flap under local anaesthesia and microscope. After operation two drops of EGF eyedrop were used, and five minutes later 0.3% Tarivid Eye Oint was used again, and then the operated eye was enswathed. Everyday the wound cornea was observed and the EGF eyedrop was used.
Results:
The wound cornea healing time of control group was seven days and that of the EGF group was five days and gave a remarkable difference (P < 0.05). The same results were obtained after comparing the effective group and ineffective group, P < 0.05.
Conclusions:
EGF eyedrop can accelerate proliferation and recovery of wound corneal epithelial cells. In the clinical trial, every body felt well and no side-effect was observed.
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