Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Iron overloading inhibits dentine mineralization.

R C De Lucca1, P M Mandalunis, A M Ubios

  • 1Department of Histology and Embryology, Faculty of Dentistry, University of Buenos Aires.

Acta Odontologica Latinoamericana : AOL
|August 9, 2003
PubMed
Summary

Iron intoxication inhibits dentine mineralization in rats, leading to non-mineralized dentine but mineralized bone. This suggests distinct bone and dentine mineralization processes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impairment of rat tooth eruption in pups born to mothers exposed to chronic stress during pregnancy.

Archives of oral biology·2013
Same author

Effect of monosodium olpadronate on osteoclasts and megakaryocytes: an in vivo study.

Journal of musculoskeletal & neuronal interactions·2009
Same author

Catch-up of delayed tooth eruption associated with uranium intoxication.

Health physics·2007
Same author

Ultrastructural and metabolic changes in osteoblasts exposed to uranyl nitrate.

Archives of toxicology·2006
Same author

Bone response to different strength orthodontic forces in animals with periodontitis.

Journal of periodontal research·2005
Same author

Root resorption in deciduous teeth after applying orthodontic forces.

The Journal of clinical pediatric dentistry·2005

Area of Science:

  • Biomineralization
  • Dental Research
  • Toxicology

Background:

  • Dentine and bone mineralization are crucial biological processes.
  • Understanding these processes is vital for dental and skeletal health.
  • Iron's role in mineralization requires further investigation.

Purpose of the Study:

  • To investigate the effect of iron intoxication on dentine mineralization.
  • To compare the mineralization processes of dentine and bone under iron exposure.
  • To explore potential differences in mineralization mechanisms between dentine and bone.

Main Methods:

  • Wistar rats were used as the animal model.
  • Iron dextran was administered intraperitoneally to induce intoxication.
  • Bisodium etidronate (EHBP) and saline were used as comparative treatments and control.

Main Results:

  • Iron intoxication resulted in non-mineralized dentine and mineralized bone.
  • Bisodium etidronate treatment also led to non-mineralized dentine and bone.
  • These outcomes indicate differential responses of dentine and bone to mineralization inhibitors.

Conclusions:

  • Iron intoxication significantly impairs dentine mineralization.
  • Bone and dentine appear to possess distinct mineralization mechanisms.
  • Further research is warranted to elucidate these differing pathways.

Related Experiment Videos